Recent research has found that square wave 1000 Hz stimulation to the brain was effective in treating acute depression, even in those on medical therapies. Medical therapies unfortunately can take several weeks to actually take effect. This is a very vulnerable time for many people. P6 (1000 Hz) was added to the FlexPulse to help to improve mood. While P5 could also be useful for this purpose, P6 would be recommended for those with recent onset of brief, reactive depression, or even more significant levels of depression, stress or mood change.
1 kHz (1000 Hz) square wave signal has been tested (Rohan) for the treatment of depression. The intensity of the device is about 20 G. The randomized, double blind, sham controlled study was in a large group of stably medicated, depressed patients with either bipolar disorder (BPD) (n = 41) or major depressive disorder (n = 22). Subjects received a single, 20-minute treatment. Change in mood was assessed immediately afterward using a visual analog scale (VAS), the 17-item Hamilton Depression Rating Scale (HDRS-17), and the Positive and Negative Affect Schedule scales. Substantial improvement (>10% of baseline) in mood was observed following LFMS treatment relative to sham treatment for both diagnostic subgroups, in the VAS and the HDRS-17. These differences were statistically significant across the two diagnostic groups (p = .01 VAS, p = .02 HDRS-17). Rapid improvement in mood was found using the Positive and Negative Affect Schedule scales (positive affect scale p = .02 BPD, p = .002 combined group). There appears to be a broad penetration of the magnetically-induced electric field throughout the cerebral cortex. They concluded by saying that low intensity PEMF stimulation may produce rapid changes in mood.
P6 is not proven by any government authority as a formal depression therapy. Coil placements for P6 should be to the top of the head, side-by-side, typically under a hat or cap. Stimulation time could be anywhere from 10 to 30 minutes.